EFFECTIVENESS AND SIDE EFFECTS OF USING METHOTREXATE AND ADALIMUMAB IN THE TREATMENT OF RHEUMATOID ARTHRITIS PATIENTS

Rheumatoid arthritis (RA) is one of the diseases autoimmune systemic progressively characterized by inflammation membrane synovial that coating joints. Methotrexate (MTX) and Adalimumab are drugs commonly used in treatment. This study aimed to look at effectiveness safety both either monotherapy a combination them. review article experimental studies with data retrieval retrospectively on database has been set, namely PubMed, Google Scholar, Portal Garuda were conducted for 6 mo. The use adalimumab showed improvement based value DAS28-4(ESR) HAQ-DI when compared methotrexate. side effects caused MTX risk was more than 2% adalimumab. Several drug carriers determinants therapeutic efficacy, such as sRNA (small interfering-RNA), LPNP (hybrid lipid-polymers nanoparticles), FRβ (Folate-receptor β), NF-κB (nuclear factor kappa-light-chain-enhancer activated B-cells), β-GP (β-Glycerophosphate). slightly better methotrexate but diverse less risk. does not have significant difference, from lower alone.